Description
Could Parkinson’s disease actually start in your gut, not your brain? Discover why healing your microbiome health might be the secret to treating and preventing neurological diseases for brain function through biological systems and gut health.
Dr. Mark Hyman talks with Sarkis Mazmanian, PhD, a professor of microbiology at Caltech whose research explores how gut bacteria influence the brain. We discuss why the gut has become an important focus in Parkinson’s research and how understanding that connection could open new possibilities for treatment.
Here’s what we get into:
- How the bacteria in your gut communicate with your brain and may influence behavior
- Why digestive problems can show up years before the movement symptoms of Parkinson’s
- What mouse studies suggest about the microbiome and autism, and what we still need to learn in people
- Whether commercial microbiome tests and probiotics can deliver on their promises
- Ways to support your gut through food, sleep, movement, and managing stress
When someone comes into my office, I want to understand their whole story, including what was changing long before they came to see me. That’s what makes the gut connection so compelling in Parkinson’s. If changes are happening years before movement problems appear, could that give us an earlier opportunity to help? It’s a question worth asking, especially when the answer could mean more years of doing the things you love.
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0:00 The Microbiome and Brain Health
4:13 Gut Signals to the Brain
11:33 Autism, Metabolites, and Animal Models
23:53 Measuring Change in Autism
33:17 A Bacteria That Seals the Gut
38:01 Leaky Gut and Microbial Balance
45:08 Human Microbiomes in Mice
49:08 Parkinson’s Starts in the Gut
55:29 Systemic Roots of Neurologic Disease
1:01:52 What to Do for a Healthy Gut
1:05:36 Autism, Parkinson’s, and Reversibility
1:11:11 Building Microbiome Health Early